+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study



Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study



Hepatology Research 36(1): 61-69



Introduction: To identify high risk alleles for gallstone disease, we analyzed association of LDLR AvaII, LRPAP1 insertion/deletion, CETP TaqI B, and LPL HindIII polymorphisms with gallstone disease.Methods: In DNA samples of 214 gallstone patients and 322 age and sex matched controls, specific region containing polymorphisms was PCR amplified and digested with restriction enzymes except for LRPAP1 insertion/deletion polymorphism.Results: LRPAP1 gene insertion/deletion polymorphism was found to be significantly associated with gallstone disease. Genotype 11 was conferring significant risk for gallstone disease in females only (P = 0.019; OR 2.577, 95% CI 1.144-5.806). LDLR AvaII, CETP TaqI B, and LPL HindIII polymorphisms were not found to be associated with gallstone disease either at genotype or allele level.Conclusions: LRPAP1, II genotype carrier females may have increased risk for gallstone disease. On the other hand, LDLR AvaII, CETP TaqI B, and LPL HindIII polymorphisms may not be associated with gallstone disease. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011786919

Download citation: RISBibTeXText

PMID: 16837242

DOI: 10.1016/j.hepres.2006.05.005


Related references

Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol 34(2-3): 115-120, 2005

Association of polymorphisms in nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol 34(2-3): 115-120, 2004

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study. Biomedical and Environmental Sciences 28(7): 510-517, 2015

Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. Journal of Gastroenterology and Hepatology 21(5): 847-849, 2006

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene. Neuroscience Letters 244(2): 65-68, 1998

Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population. Neuroscience Letters 444(1): 109-111, 2008

Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease. Neuroscience Letters 332(3): 216-218, 2002

Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease. Neuroscience Letters 316(1): 17-20, 2001

Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study. Journal of Medical Genetics 43(10): 798-803, 2006

Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study. Bmc Medical Genetics 10: 71, 2009

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology 49(1): 56-61, 1997