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B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model



B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model



Blood 106(7): 2235-2243



We report the development of a mouse B cell-depleting immunoconjugate (anti-CD22 monoclonal antibody conjugated to calicheamicin) and its in vivo use to characterize the kinetics of CD22(+) B-cell depletion and reconstitution in murine primary and secondary lymphoid tissues. The effect of B-cell depletion was further studied in a murine collagen-induced arthritis (CIA) model and a respiratory syncytial virus (RSV) vaccination model.

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Accession: 011795527

Download citation: RISBibTeXText

PMID: 15947095

DOI: 10.1182/blood-2004-11-4547


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