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Bacterial quorum-sensing signals are inactivated by mammalian cells

Bacterial quorum-sensing signals are inactivated by mammalian cells

Proceedings of the National Academy of Sciences of the United States of America 101(12): 3993-3994

Small interfering RNAs (siRNAs) potently silence expression of target genes. In principle siRNA libraries can be used to perform effective genome-scale functional genetic screens in mammalian cells, but their development has been hampered by the need to chemically synthesize thousands of oligonucleotides and to incorporate them into expression vectors.

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Accession: 011797470

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PMID: 15024108

DOI: 10.1073/pnas.0400874101

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