+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride



Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride



Hepatology Research 27(2): 117-123



The effect of branched-chain amino acids (BCAA) on the metabolism of protein, amino acids and ammonia was examined in rats with cirrhosis, with a special emphasis on the efficacy of early administration of BCAA. Liver cirrhosis was induced in rats by intraperitoneal injections of carbon tetrachloride (CCl(4)). The rats were divided into three groups: early-, late- and untreated. The early- and late-treated groups were given BCAA rich food from the early and late stage of liver cirrhosis, while the untreated group was given standard food throughout. Concentrations of amino acids and ammonia in the plasma and the ornithine carbamyl transferase (OCT) activity in the liver were evaluated, and compared with control group after 15 weeks maintenance. Ammonia was significantly higher in the late- and untreated groups, but not in the early-treated group. BCAA, tyrosine, and methionine were significantly lower in the untreated and late-treated groups. Glutamine increased significantly in the un-, late- and early-treated groups. However, no significant differences were found among three groups. A significant difference was found in 3-methyl histidine (3-MH) between the early- and late-treated groups. This study suggests that the administration of BCAA from early stage of liver cirrhosis inhibits breakdown of protein and improves metabolism of protein, amino acids and ammonia.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011801533

Download citation: RISBibTeXText

PMID: 14563425

DOI: 10.1016/s1386-6346(03)00204-3


Related references

Oral supplementation with branched-chain amino acids improves transthyretin turnover in rats with carbon tetrachloride-induced liver cirrhosis. Journal of Nutrition 126(5): 1412-1420, 1996

Oral supplementation with branched-chain amino acids improves survival rate of rats with carbon tetrachloride-induced liver cirrhosis. Digestive Diseases and Sciences 43(7): 1572-1579, 1998

Oral Supplementation with Branched-Chain Amino Acids Improves Transthyretin Turnover in Rats with Carbon Tetrachloride-Induced Liver Cirrhosis. The Journal of Nutrition 126(5): 1412-1420, 1996

Body protein metabolism and plasma amino acids in cirrhosis of the liver. The effect of varying the branched chain amino acid content of intravenous amino acid solutions. Clinical Nutrition 3(3): 153-162, 1984

Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis. American Journal of Physiology. Gastrointestinal and Liver Physiology 288(6): G1292-G1300, 2004

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 3. effects of administration of short chain fatty acid on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 642-651, 1981

Effect of branched-chain amino acid-rich parenteral nutrition on protein metabolism after partial hepatectomy in rats with liver cirrhosis. Nan Fang Yi Ke Da Xue Xue Bao 27(11): 1721-1723, 2007

Evaluation of the effects of combination therapy with branched-chain amino acid and zinc supplements on nitrogen metabolism in liver cirrhosis. Hepatology Research 37(8): 615-619, 2007

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 2. effects of administration of ammonia on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 630-641, 1981

Effect of branched chain amino acid infusions on body protein metabolism in cirrhosis of liver. Gut 27(Suppl. 1): 96-102, 1986

The role of branched-chain amino acids and aromatic amino acids of various tissues and the degenerations of skeletal muscle fiber in liver cirrhosis model rat. Gastroenterology 118(4 Suppl 2 Part 1): AGA A773, 2000

Usefulness of branched-chain amino acids to tyrosine mole ratio to detect the amino acid imbalance in well-compensated liver cirrhosis. Hepatology 30(4 Part 2): 615A, 1999

Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatology Research 35(3): 204-214, 2006

Differences in branched-chain amino acid catabolism between acute liver failure and liver cirrhosis in rats. FASEB Journal 17(4-5): Abstract No. 431-3, 2003

Branched-chain amino acids as a protein- and energy-source in liver cirrhosis. Biochemical and Biophysical Research Communications 313(2): 405-409, 2004