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Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

Li, T.; Jahan, A.; Chiang, J.Y.L.

Hepatology 43(6): 1202-1210

2006

ISSN/ISBN: 0270-9139
PMID: 16729332
DOI: 10.1002/hep.21183
Accession: 011803934
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Cholesterol 7 alpha-hydroxylase (CYP7A1) of the bile acid biosynthesis pathway is suppressed by bile acids and inflammatory cytokines. Bile acids are known to induce inflammatory cytokines to activate the mitogen-activated protein kinase/c-jun N-terminal kinase (JNK) signaling pathway that inhibits CYP7A1 gene transcription. c-jun has been postulated to mediate bile acid inhibition of CYP7A1. However, the c-Jun target involved in the regulation of CYP7A1 is unknown.

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

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Related References

Tiangang, L.I.; Jahan, A.; Chiang, J.Y.L. 2006: Bile acids and cytokines inhibit the human cholesterol 7α-hydroxylase gene via the JNK/c-jun pathway in human liver cells Hepatology (Baltimore, Md.) 43(6): 1202-1210
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