Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells
Li, T.; Jahan, A.; Chiang, J.Y.L.
Hepatology 43(6): 1202-1210
ISSN/ISBN: 0270-9139 PMID: 16729332 DOI: 10.1002/hep.21183
Cholesterol 7 alpha-hydroxylase (CYP7A1) of the bile acid biosynthesis pathway is suppressed by bile acids and inflammatory cytokines. Bile acids are known to induce inflammatory cytokines to activate the mitogen-activated protein kinase/c-jun N-terminal kinase (JNK) signaling pathway that inhibits CYP7A1 gene transcription. c-jun has been postulated to mediate bile acid inhibition of CYP7A1. However, the c-Jun target involved in the regulation of CYP7A1 is unknown.