+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis



Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis



Apmis 112(7-8): 526-538



The pace of research into the lymphatic system continues to accelerate with the availability of new molecular markers. One such marker, LYVE-1, the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan, has been a key component of many important studies on embryonic and tumour-induced lymphangiogenesis, and continues to be used for the detection and isolation of lymphatic endothelial cells. However, LYVE-1 is interesting in its own right. Being a member of the Link protein family whose only other major hyaluronan receptor is directly involved in leukocyte migration and tumour metastasis, LYVE-1 is already implicated in the trafficking of cells within lymphatic vessels and lymph nodes. The current challenge is to determine the precise roles played by LYVE-1 and other scavenger type receptors in the immune functions of the lymphatics as well as to use LYVE-1 and other markers to investigate the way in which tumours exploit lymphatic vessels for metastasis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011809470

Download citation: RISBibTeXText

PMID: 15563314

DOI: 10.1111/j.1600-0463.2004.apm11207-0811.x


Related references

Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1). Journal of Urology 172(1): 103-107, 2004

Evidence for lymphatic destruction in prostate carcinoma assessed with the novel lymphatic marker LYVE-1. European Urology Suppl.s 2(1): 162, 2003

LYVE-1, the lymphatic system and tumor lymphangiogenesis. Trends in Immunology 22(6): 317-321, 2001

Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Molecular and Cellular Biology 27(2): 595-604, 2007

Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. Journal of Surgical Research 151(1): 68-73, 2009

Characterization of cells expressing lymphatic marker LYVE-1 in macaque large intestine during simian immunodeficiency virus infection identifies a large population of nonvascular LYVE-1(+)/DC-SIGN(+) cells. Lymphatic Research and Biology 11(1): 26-34, 2013

Lymphatic vascular endothelial hyaluronan receptor (LYVE)-1- and CCL21-positive lymphatic compartments in the diabetic thymus. Anatomical Science International 81(4): 201-209, 2006

Lymph vessel destruction in prostatic cancer LYVE-1 as novel lymphatic marker. Pathology Research & Practice 199(4): 201, 2003

Expression and quantitation of lymphatic endothelial marker, LYVE-1, mRNA in breast cancer. Breast Cancer Research & Treatment 69(3): 265, 2001

Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1. Blood 121(7): 1229-1237, 2013

The expression of the lymphatic endothelial cell marker LYVE-1 in benign and malignant vascular tumours. Journal of Pathology 201(Suppl.): 57A, 2003

Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Developmental Dynamics 237(7): 1901-1909, 2008

Lymphangiogenesis, lymphatic endothelial cells and lymphatic metastasis in head and neck cancer--a review of mechanisms. International Journal of Oral Science 2(1): 5, 2010

Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Research 64(11): 3737-3740, 2004

Lymphangiogenesis in vitro: Formation of lymphatic capillary-like channels from confluent monolayers of lymphatic endothelial cells. In Vitro Cellular and Developmental Biology Animal 30A(8): 512-518, 1994