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Breast cancer risk during HRT: influence of estradiol metabolites on breast cancer and endothelial cell proliferation



Breast cancer risk during HRT: influence of estradiol metabolites on breast cancer and endothelial cell proliferation



Maturitas 49(3): 235-240



Objectives: Long-term hormone replacement therapy is associated with an increased breast cancer risk. Evidence is accumulating that estradiol metabolites are involved in carcinogenesis. These metabolites may have proliferating and anti-proliferative properties. We have investigated the effect of 14 metabolites on the proliferation of human breast cancer cells and on the proliferation of human vascular endothelial cells.

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Accession: 011817949

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PMID: 15488352

DOI: 10.1016/j.maturitas.2004.02.004


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