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Bridging conformational dynamics and function using single-molecule spectroscopy

Bridging conformational dynamics and function using single-molecule spectroscopy

Structure 14(4): 633-643

In a typical structure-function relation study, the primary structure of proteins or nucleic acids is changed by mutagenesis and its functional effect is measured via biochemical means. Single-molecule spectroscopy has begun to give a whole new meaning to the "structure-function relation" by measuring the realtime conformational changes of individual biological macromolecules while they are functioning.

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Accession: 011818583

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PMID: 16615904

DOI: 10.1016/j.str.2006.02.005

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