Section 12
Chapter 11,851

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil

Rodrigues, V.ív.d.F.S.; Telles, M.A.; Ribeiro, M.O.ór.; Cafrune, P.íc.I.; Rossetti, M.L.R.; Zaha, A.

Antimicrobial Agents and ChemoTherapy 49(1): 444-446


ISSN/ISBN: 0066-4804
PMID: 15616332
DOI: 10.1128/aac.49.1.444-446.2005
Accession: 011850304

Download citation:  

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

PDF emailed within 0-6 h: $19.90