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Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism



Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism



Biochemistry 44(28): 9563-9573



Protein kinase C theta (PKC theta), a member of the Ca2+-independent novel subfamily of PKCs, is required for T-cell receptor (TCR) signaling and IL2 production. PKC theta-deficient mice have impaired Th2 responses in a murine ova-induced asthma model, while Th1 responses are normal. As an essential component of the TCR signaling complex, PKC theta is a unique T-cell therapeutic target in the specific treatment of T-cell-mediated diseases.

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Accession: 011850403

Download citation: RISBibTeXText

PMID: 16008341

DOI: 10.1021/bi050608q


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