Section 12
Chapter 11,851

Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil

Kuiper, G.G.J.M.; Klootwijk, W.; Morvan Dubois, G.; Destree, O.; Darras, V.M.; Van der Geyten, S.; Demeneix, B.; Visser, T.J.

Endocrinology 147(7): 3519-3529


ISSN/ISBN: 0013-7227
PMID: 16601143
DOI: 10.1210/en.2005-0711
Accession: 011850472

Download citation:  

In frogs such as Rana and Xenopus, metamorphosis does not occur in the absence of a functional thyroid gland. Previous studies indicated that coordinated development in frogs requires tissue and stage-dependent type II and type III iodothyronine deiodinase expression patterns to obtain requisite levels of intracellular T-3 in tissues at the appropriate stages of metamorphosis.

PDF emailed within 0-6 h: $19.90