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Chiral separation of anticholinergic drug enantiomers in nonaqueous capillary electrophoresis



Chiral separation of anticholinergic drug enantiomers in nonaqueous capillary electrophoresis



Journal of Chromatography. A 1074(1-2): 195-200



Nonaqueous capillary electrophoretic (NACE) method for the separation of nine structurally similar chiral anticholinergic drugs was developed. The eight drug enantiomers were separated on baseline within 18 min using 20 mM phosphoric acid and 10 mM NaOH, containing 10 mM heptakis(2,3-dimethyl-6-sulfato)-beta-cyclodextrin (HDMS-beta-CD) in methanol. The results were compared with those obtained in the high performance liquid chromatography system. (c) 2005 Elsevier B.V.

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Accession: 011855791

Download citation: RISBibTeXText

PMID: 15941055

DOI: 10.1016/j.chroma.2005.03.009


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