+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes

Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes

Circulation Journal 69(8): 987-990

Background Enhanced expression of G protein-coupled receptor kinase (GRK) has been reported in failing hearts and in the present study the stability of enhanced GRK mRNA expression, and the correlation between the expression level of GRK mRNA in peripheral lymphocytes and in the heart were both evaluated.Methods and Results Isoproterenol was injected into rats for 2 weeks, and then GRK5 mRNA was assessed by quantitative reverse transcriptase-palymerase chain reaction.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 011858907

Download citation: RISBibTeXText

PMID: 16041172

Related references

Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: Effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK61. Journal of Pharmacology & Experimental Therapeutics 284(3): 1218-1226, 1998

Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. Journal of Biological Chemistry 289(38): 26119-26130, 2015

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro. Biochemistry 54(28): 4320-4329, 2015

G protein-coupled receptor kinases, beta-adrenergic receptor desensitization and the heart. M-S (Medecine Sciences) 14(2): 210-214, 1998

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation 98(17): 1783-1789, 1998

Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 (GRK2). FEBS Letters 518(1-3): 195-199, 2002

Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Journal of Biological Chemistry 270(30): 17953-17961, 1995

Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Molecular Pharmacology 77(3): 405-415, 2010

Clathrin Required for Phosphorylation and Internalization of (Sb(b2(B-Adrenergic Receptor by G Protein-coupled Receptor Kinase 2 (GRK2). Journal of biological chemistry20 281(42): 31940-31949, 2006

Myocardial and peripheral lymphocytic transcriptomic dissociation of beta-adrenoceptors and G protein-coupled receptor kinases in heart transplantation. Journal of Heart and Lung Transplantation 28(11): 1166-1171, 2010

Clathrin required for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2). Journal of Biological Chemistry 281(42): 31940-9, 2006

Chronic catecholamine infusion enhanced the expression of G-protein coupled receptor kinases in hearts and circulating lymphocytes. Circulation 98(17 SUPPL ): I123, Oct 27, 1998

Role of protein kinases in the desensitization sensitization of beta adrenergic receptor and prostaglandin receptor stimulation of adenylyl cyclase. Konijn, T M , M D Houslay And P J M Van Haastert (Ed ) Nato Asi (Advanced Science Institute) Series Series H Cell Biology, Vol 44 Activation And Desensitization Of Transducing Pathways; Workshop, Noordwijkerhout, Netherlands, May 25-27, 1989 Xi+320p Springer-Verlag New York, Inc : Secaucus, New Jersey, Usa; Berlin, West Germany Illus 115-132, 1990

Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. Journal of Clinical Investigation 95(3): 1271-1280, 1995

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. Journal of Biological Chemistry 269(9): 6832-6841, 1994