+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Concomitant hepatocellular carcinoma and non-Hodgkin's lymphoma in a patient with nodular regenerative hyperplasia



Concomitant hepatocellular carcinoma and non-Hodgkin's lymphoma in a patient with nodular regenerative hyperplasia



Pathology International 56(5): 279-282



Hepatocellular carcinoma (HCC) is the most common primary cancer in the liver. Liver invasion of non-Hodgkin's lymphoma (NHL) is also often observed. But simultaneous existence of HCC and NHL in a liver is extremely rare. Such patients reported previously had cirrhotic livers. Herein is reported a patient who simultaneously had HCC and NHL in a liver without cirrhosis, but with nodular regenerative hyperplasia (NRH). NHL was of the diffuse large B-cell type. Lymphoma cells invaded the portal vein, and formed thrombi. These thrombi would contribute to the development of NRH by decreasing portal vein blood flow. HCC was of the well-differentiated type and there was a 2 cm-sized nodule at the lateral segment. There is the possibility that NRH was associated with the HCC because NRH is reported as a premalignant lesion. HCC and NHL were colocalized in the liver without hepatic virus infection or cirrhosis, although common cause(s) of development of these malignancies remain unclear in the present case.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011892447

Download citation: RISBibTeXText

PMID: 16669877

DOI: 10.1111/j.1440-1827.2006.01956.x


Related references

Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis. European Journal of Gastroenterology and Hepatology 13(3): 287-290, 2001

Hemoperitoneum as the first manifestation of hepatic regenerative nodular hyperplasia associated with Hodgkin's lymphoma. Revista Clinica Espanola 184(6): 333, 1989

A case of non-Hodgkin's lymphoma with portal hypertension and nodular regenerative hyperplasia. Nihon Shokakibyo Gakkai Zasshi 91(12): 2239-2243, 1994

Nodular regenerative hyperplasia, dysplasia, and hepatocellular carcinoma. American Journal of Gastroenterology 91(5): 836-837, 1996

Nodular Regenerative Hyperplasia of the Liver in Hepatocellular Carcinoma. Journal of Clinical Gastroenterology 16(2): 155-159, 1993

Regenerative nodular hyperplasia, hepatocellular carcinoma and oral contraceptives. Gastroenterologie Clinique et Biologique 8(10): 768-769, 1984

Hepatocellular carcinoma and nodular regenerative hyperplasia: possible pathogenetic relationship. American Journal of Gastroenterology 91(5): 879-884, 1996

Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma. Hepatology 60(4): 1440-1441, 2014

Nodular regenerative hyperplasia of the liver in hepatocellular carcinoma. An autopsy study. Journal of Clinical Gastroenterology 16(2): 155-159, 1993

Patients with nodular regenerative hyperplasia should be considered for hepatocellular carcinoma screening. Hepatology Research 44(6): 689-693, 2014

Clinical characteristics of nodular regenerative hyperplasia ; difficult to differentiate from hepatocellular carcinoma. Gastroenterology 112(4 Suppl. ): A1315, 1997

Focal nodular hyperplasia with concomitant hepatocellular carcinoma: a case report and clonal analysis. Journal of Clinical Pathology 57(5): 556-559, 2004

Hepatocellular carcinoma arising in primary biliary cirrhosis presenting with nodular regenerative hyperplasia: report of an autopsy case. Journal of Gastroenterology and Hepatology 21(12): 1866-1868, 2006

Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundación santa fe de bogotá. Case Reports in Pathology 2014: 193802, 2014

Peripheral neuropathy, coagulopathy and nodular regenerative hyperplasia of the liver in a patient with multiple serologic auto-antibody activities and IgM B-cell lymphoma. Journal of Internal Medicine 226(5): 291-295, 1989