+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range



Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range



Journal of Virology 80(22): 10909-10918



To study the process of spike (S)-receptor interaction during coronavirus entry, we evaluated the contributions of mutations in different regions of the murine hepatitis virus (MRV) S protein to natural receptor murine carcinoembryonic antigen-related cell adhesion molecule la (CEACAM1a) dependence and to the acquisition of extended host range. Extended-host-range variants of MHV strain A59 were previously obtained from persistently infected cells (J. H. Schickli, B. D. Zelus, D.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011902891

Download citation: RISBibTeXText

PMID: 16956938

DOI: 10.1128/jvi.00950-06


Related references

The N-terminal region of the murine coronavirus spike glycoprotein is associated with the extended host range of viruses from persistently infected murine cells. Journal of Virology 78(17): 9073-9083, 2004

Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor. Journal of Virology 79(22): 14451-6, 2005

Evidence for a common evolutionary origin of coronavirus spike protein receptor-binding subunits. Journal of Virology 86(5): 2856-2858, 2012

Analysis of the receptor-binding site of murine coronavirus spike protein. Journal of Virology 70(4): 2632-2636, 1996

The S2 subunit of the murine coronavirus spike protein is not involved in receptor binding. Journal of Virology 69(11): 7260-7263, 1995

Localization of neutralizing epitopes and receptor-binding site in murine coronavirus spike protein. Advances in Experimental Medicine and Biology 380: 359-365, 1995

Identification of spike protein residues of murine coronavirus responsible for receptor-binding activity by use of soluble receptor-resistant mutants. Journal of Virology 71(12): 9024-9031, 1997

The murine coronavirus mouse hepatitis virus strain A59 from persistently infected murine cells exhibits an extended host range. Journal of Virology 71(12): 9499-9507, 1997

Amino acid substitutions and an insertion in the spike glycoprotein extend the host range of the murine coronavirus MHV-A59. Virology 324(2): 510-524, 2004

Substitutions of conserved amino acids in the receptor-binding domain of the spike glycoprotein affect utilization of murine CEACAM1a by the murine coronavirus MHV-A59. Virology 334(1): 98-110, 2005

Localization of neutralizing epitopes and the receptor-binding site within the amino-terminal 330 amino acids of the murine coronavirus spike protein. Journal of Virology 68(9): 5403-5410, 1994

Involvement in fusion activity of an epitope in the S2 subunit of murine coronavirus spike protein. Advances in Experimental Medicine and Biology 494: 213-218, 2001

Murine coronavirus spike glycoprotein. Receptor binding and membrane fusion activities. Advances in Experimental Medicine and Biology 494: 183-192, 2001

Functional analysis of an epitope in the S2 subunit of the murine coronavirus spike protein: involvement in fusion activity. Journal of General Virology 81(Pt 12): 2867-2871, 2000

Receptor-induced conformational changes of murine coronavirus spike protein. Journal of Virology 76(23): 11819-11826, 2002