+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

Diabetes 54(2): 452-461

Cytokines and free radicals are mediators of P-cell death in type I diabetes. Under in vitro conditions, interleukin-lbeta (IL-1beta) + gamma-interferon (IFN-gamma) induce nitric oxide (NO) production and apoptosis in rodent and human pancreatic R-cells.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 011918487

Download citation: RISBibTeXText

PMID: 15677503

Related references

IL-1beta caused pancreatic beta-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway. Molecular and Cellular Biochemistry 324(1-2): 183-190, 2009

Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Molecular Cancer Therapeutics 9(3): 718-730, 2010

Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib. Journal of Neuroscience Research 91(3): 393-406, 2013

Asymmetric dimethylarginine downregulates sarco/endoplasmic reticulum calcium‑ATPase 3 and induces endoplasmic reticulum stress in human umbilical vein endothelial cells. Molecular Medicine Reports 16(5): 7541-7547, 2017

Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cells. Plos One 7(11): E48626, 2013

Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca 2+ Regulation. Hypertension 69(4): 625-632, 2017

Endoplasmic Reticulum Oxidoreductin-1-Like beta ERO1lbeta Regulates Susceptibility to Endoplasmic Reticulum Stress and Is Induced by Insulin Flux in beta-Cells. 2011

Endoplasmic reticulum protein 29 is involved in endoplasmic reticulum stress in islet beta cells. Molecular Medicine Reports 13(1): 398-402, 2016

Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress. Journal of Alzheimer's Disease 20(1): 261-273, 2010

Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca 2+ -ATPase 2 Expression in Diabetic Nephropathy. Frontiers in Pharmacology 7: 500, 2017

Globular adiponectin attenuates myocardial ischemia/reperfusion injury by upregulating endoplasmic reticulum Ca²⁺-ATPase activity and inhibiting endoplasmic reticulum stress. Journal of Cardiovascular Pharmacology 62(2): 143-153, 2014

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. Journal of Biological Chemistry 279(35): 37030-9, 2004

The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein. Journal of Biological Chemistry 275(29): 22363-22372, 2000

The sequence of the structural changes in the endoplasmic reticulum rough endoplasmic reticulum and smooth endoplasmic reticulum during the synthesis of drug metabolizing enzymes in the liver. African Journal of Medicine & Medical Sciences 11(3): 135-150, 1982

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell. Journal of Biological Chemistry 289(47): 32798-32810, 2015