DG-CST (Disease Gene Conserved Sequence Tags) , a database of human-mouse conserved elements associated to disease genes

Boccia, A.; Petrillo, M.; di Bernardo, D.; Guffanti, A.; Mignone, F.; Confalonieri, S.; Luzi, L.; Pesole, G.; Paolella, G.; Ballabio, A.; Banfi, S.

Nucleic Acids Research 33(Database Issue): D505-D510


ISSN/ISBN: 1362-4962
PMID: 15608249
DOI: 10.1093/nar/gki011
Accession: 011920467

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The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human-mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts.