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Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats



Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats



Journal of Pharmacy and Pharmacology 56(10): 1259-1266



We examined the effects of high-dose methylprednisolone on the bioavailability of orally administered ciclosporin in rats. To emulate the clinical protocol of methylprednisolone pulse therapy, methylprednisolone sodium succinate (MPS), a prodrug of methylprednisolone, was intravenously administered as repeated doses (66.3 mg kg-1) for 3 days.

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Accession: 011924795

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PMID: 15482640

DOI: 10.1211/0022357044481


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