+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ

Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ

Cancer Research 65(3): 681-685

A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor alpha expression in mammary epithelial cells developed ductal hyperplasia (DH), lobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 months of age. Higher proliferative rates were found in both normal and abnormal ductal and lobular structures. DH and DCIS but not normal ductal structures showed an increased percentage of cells with nuclear-localized cyclin D1.

(PDF emailed within 1 workday: $29.90)

Accession: 011931655

Download citation: RISBibTeXText

PMID: 15705859

Related references

Dysregulating expression of Estrogen Receptor alpha in mammary epithelial cells results in developmental abnormalities and ductal hyperplasia. FASEB Journal 18(4-5): Abst 147 8, 2004

Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu. Cancer Research 62(10): 2798-2805, 2002

Estrogen promotes mammary tumor development in C3(1)/SV40 large T-antigen transgenic mice: Paradoxical loss of estrogen receptor alpha expression during tumor progression. Cancer Research 60(24): 6901-6910, 2000

Analysis of estrogen receptor (ER) and estrogen-dependent pS2 protein expression in cells of mammary ductal carcinoma. Folia Histochemica et Cytobiologica 39(2): 141-142, 2001

Transgenic mice expressing a dominant-negative type II TGFbeta receptor in mammary epithelia spontaneously develop ductal carcinoma in situ. Proceedings of the American Association for Cancer Research Annual Meeting 42: 422, March, 2001

Androgen receptor expression in ductal carcinoma in situ of the breast: not a helpful marker for classification such as estrogen receptor alpha and progesterone receptor. Applied Immunohistochemistry & Molecular Morphology 13(1): 25-29, 2005

Estrogen receptor alpha and beta, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast. Oncology Reports 12(4): 695-699, 2004

Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America 104(37): 14718-14723, 2007

Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice. Journal of Steroid Biochemistry and Molecular Biology 95(1-5): 9-15, 2005

P53 protein expression in mammary ductal carcinoma in situ: Relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein. Human Pathology 24(5): 463-468, 1993

Co-expression of estrogen receptor-alpha and targets of estrogen receptor action in proliferating monkey mammary epithelial cells. Breast Cancer Research 8(1): R10-R10, 2006

Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer Research 70(10): 3965-3974, 2010

Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology 143(6): 2357-2365, 2002

Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ. Cancer Research 70(11): 4698-4708, 2010