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Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling



Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling



Molecular Pharmacology 69(5): 1763-1771



We identified dexamethasone-induced Ras protein 1 (Dexras1) as a negative regulator of protein kinase C (PKC) delta, and the consequences of this regulation have been examined for adenylyl cyclase (EC 4.6.1.1) type 2 (AC2) signaling. Dexras1 expression in human embryonic kidney 293 cells completely abolished dopamine D-2 receptor-mediated potentiation of AC2 activity, which is consistent with previous reports of its ability to block receptor-mediated G beta gamma signaling pathways.

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Accession: 011948819

Download citation: RISBibTeXText

PMID: 16489124

DOI: 10.1124/mol.105.019133


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