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Dextran sulfate suppresses cell adhesion and cell cycle progression of melanoma cells



Dextran sulfate suppresses cell adhesion and cell cycle progression of melanoma cells



Anticancer Research 25(2a): 895-902



We have reported that dextran sulfate is a possible candidate for an antimetastatic drug because it inhibits cell adhesion. It has been demonstrated that dextran sulfate can detach cancer cells adhering to the bottom of plastic flasks, and that the detached cells do not readhere or proliferate. In this study, we investigated the effects of dextran sulfate on cancer cells, focusing on cell cycle regulators as well as cell adhesion molecules.

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Accession: 011948885

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PMID: 15868925



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