+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Dextran sulfate suppresses cell adhesion and cell cycle progression of melanoma cells

Dextran sulfate suppresses cell adhesion and cell cycle progression of melanoma cells

Anticancer Research 25(2a): 895-902

We have reported that dextran sulfate is a possible candidate for an antimetastatic drug because it inhibits cell adhesion. It has been demonstrated that dextran sulfate can detach cancer cells adhering to the bottom of plastic flasks, and that the detached cells do not readhere or proliferate. In this study, we investigated the effects of dextran sulfate on cancer cells, focusing on cell cycle regulators as well as cell adhesion molecules.

(PDF emailed within 1 workday: $29.90)

Accession: 011948885

Download citation: RISBibTeXText

PMID: 15868925

Related references

Inhibition of experimental metastasis and cell adhesion of murine melanoma cells by chondroitin sulfate-derivatized lipid, a neoproteoglycan with anti-cell adhesion activity. Clinical & Experimental Metastasis. 15(2): 83-93, 1997

Down-regulation of Pkd2 by siRNAs suppresses cell-cell adhesion in the mouse melanoma cells. Molecular Biology Reports 37(5): 2387-2395, 2010

RASSF1A suppresses melanoma development by modulating apoptosis and cell-cycle progression. Journal of Cellular Physiology 226(9): 2360-2369, 2011

Dextran sulfate inhibited neutrophil adhesion to endotoxin-activated vascular endothelial cells via E-selectin-mediated cell adhesion under nonstatic conditions. Journal of Endotoxin Research 3(SUPPL 1): 21, 1996

Ginsenoside 20(S)-Protopanaxadiol Suppresses Viability of Human Glioblastoma Cells via Down-regulation of Cell Adhesion Proteins and Cell-cycle Arrest. Anticancer Research 36(3): 925-932, 2016

Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology 140(12): 5962-5970, 1999

Lipid raft specific knockdown of SRC family kinase activity inhibits cell adhesion and cell cycle progression of breast cancer cells. Cancer Research 67(17): 8139-8148, 2007

Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension. Cytokine & Growth Factor Reviews 16(4-5): 395-405, 2005

Modulation of adhesion of CD34+ cells to extracellular matrix by expansion cytokines Reversible adhesion defect correlates with cell cycle progression. Blood 94(10 SUPPL 1 PART 1): 43a, Nov 15, 1999

RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells. International Journal of Molecular Medicine 12(5): 767-769, 2003

NB1011, a novel drug that targets tumor cells overexpressing thymidylate synthase, suppresses tumor cell growth by inducing p21, Bax, GADD45 and blocking G2/M cell cycle progression. Proceedings of the American Association for Cancer Research Annual Meeting 43: 959, March, 2002

Osthole induces apoptosis, suppresses cell-cycle progression and proliferation of cancer cells. Anticancer Research 34(11): 6473-6480, 2015

Cell cycle perturbations induced by loss of integrin-mediated cell-substrate adhesion in melanoma cell lines. British Journal of Cancer 80(SUPPL 2): 25, July, 1999

Expression of alpha CP-4 inhibits cell cycle progression and suppresses tumorigenicity of lung cancer cells. International Journal of Cancer 122(7): 1512-1520, 2008