+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Dialyzer membrane type and reuse practice influence polymorphonuclear leukocyte function in hemodialysis patients



Dialyzer membrane type and reuse practice influence polymorphonuclear leukocyte function in hemodialysis patients



Kidney International 65(2): 682-691



Polymorphonuclear leukocyte (PMNL) production of reactive oxygen species (ROS) has been linked to hemodialysis (HD) associated morbidity. The effect of dialyzer membrane type and reuse on PMNL function has not been clearly defined. The present report is a cross-sectional study undertaken in a cohort of patients undergoing regular HD, at enrollment into the Hemodialysis (HEMO) Study, to study the association between patient and dialysis-related factors and PMNL function. PMNL function was assessed by measuring PMA- and N-formyl methionyl-leucyl-phenylalanine (fMLP) -induced respiratory burst, and phagocytic activity toward Staphylococcus aureus. PMNL from patients dialyzed with polysulphone (PS) or cuprophane (CU) membranes showed higher PMA-induced respiratory burst activity compared with those exposed to substituted cellulose (cellulose acetate, cellulose triacetate, CA/CT) membranes, regardless of dialyzer reuse. The use of bleach as a cleansing agent during reuse was associated with higher PMA-induced PMNL superoxide production, as was the use of renalin when compared to aldehydes. In a subgroup of patients using PS dialyzers, reuse itself was associated with higher fMLP-induced superoxide production. The type of bleach-germicide combination during reuse showed that use of renalin as a germicide was also associated with higher PMNL phagocytosis index. The number of years on HD correlated inversely with PMA-induced PMNL superoxide response. Weaker PMNL response to fMLP was associated with greater comorbidity and poor functional status as quantified by Index of Coexisting Diseases (ICED) and Karnofsky scores, respectively. Our results indicate that dialyzer membrane type and the reuse process influence the oxidative response of PMNL among HD patients. The implications of these observations on clinical morbidity need to be further evaluated in prospective studies.

(PDF emailed within 0-6 h: $19.90)

Accession: 011950848

Download citation: RISBibTeXText

PMID: 14717942

DOI: 10.1111/j.1523-1755.2004.00429.x


Related references

Effect of dialyzer membrane and dialyzer reuse on plasma lipid levels in end stage renal disease patients on hemodialysis. Journal of the American Society of Nephrology 7(9): 1494, 1996

Effect of dialyzer membrane and dialyzer reuse on serum lipid levels in end stage renal disease patients on hemodialysis. Journal of the American Society of Nephrology 6(3): 585, 1995

Impact of dialyzer membrane on apoptosis and function of polymorphonuclear cells and cytokine synthesis by peripheral blood mononuclear cells in hemodialysis patients. Artificial Organs 31(12): 887-892, 2007

Influence of erythropoietin on dialyzer reuse, heparin need, and urea kinetics in maintenance hemodialysis patients. American Journal of Kidney Diseases 23(1): 52-59, 1994

The relative influence of dialysis adequacy and type of dialyzer membrane on protein intake in chronic hemodialysis patients. Journal of the American Society of Nephrology 6(3): 575, 1995

Dialyzer reuse: Interaction between dialyzer membrane, disinfectant (formalin), and blood during dialyzer reprocessing. Artificial Organs 20(1): 53-55, 1996

Effect of dialyzer membrane and dialyzer reuse on plasma lipid levels in end stage renal disease patients Results of a pilot study. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 249A, Sept, 1997

Hospitalization of hemodialysis patients in the US The impact of dialyzer reuse. Journal of the American Society of Nephrology 7(9): 1385, 1996

Effect of dialyzer reuse on survival of patients on hemodialysis. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 202A, Sept, 1997

Decrease of polymorphonuclear leukocyte membrane fluidity in uremic patients on hemodialysis. Nephron 54(1): 36-41, 1990

Effect of dialyzer reuse on survival of patients treated with hemodialysis. JAMA 276(8): 620-625, 1996

Association of dialyzer reuse and hospitalization rates among hemodialysis patients in the US. American Journal of Nephrology 19(6): 641-648, 1999

Morbidity of nondiabetic home hemodialysis patients with and without dialyzer reuse. Transactions - American Society for Artificial Internal Organs 28: 385-386, 1982

Trends in dialyzer membrane use and reuse practice and associated mortality in 1999-2000. Journal of the American Society of Nephrology 12(Program and Abstract Issue): 274A-275A, September, 2001