+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation

Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation

Journal of Immunology 172(5): 2894-2902

ISSN/ISBN: 0022-1767

PMID: 14978091

Allergic airway inflammation and hyperreactivity are modulated by gammadelta T cells, but different experimental parameters can influence the effects observed. For example, in sensitized C57BL/6 and BALB/c mice, transient depletion of all TCR-delta+ cells just before airway challenge resulted in airway hyperresponsiveness (AHR), but caused hyporesponsiveness when initiated before i.p. sensitization. Vgamma4+ gammadelta T cells strongly suppressed AHR; their depletion relieved suppression when initiated before challenge, but not before sensitization, and they suppressed AHR when transferred before challenge into sensitized TCR-Vgamma4-/-/6-/- mice. In contrast, Vgamma1+ gammadelta T cells enhanced AHR and airway inflammation. In normal mice (C57BL/6 and BALB/c), enhancement of AHR was abrogated only when these cells were depleted before sensitization, but not before challenge, and with regard to airway inflammation, this effect was limited to C57BL/6 mice. However, Vgamma1+ gammadelta T cells enhanced AHR when transferred before challenge into sensitized B6.TCR-delta-/- mice. In this study Vgamma1+ cells also increased levels of Th2 cytokines in the airways and, to a lesser extent, lung eosinophil numbers. Thus, Vgamma4+ cells suppress AHR, and Vgamma1+ cells enhance AHR and airway inflammation under defined experimental conditions. These findings show how gammadelta T cells can be both inhibitors and enhancers of AHR and airway inflammation, and they provide further support for the hypothesis that TCR expression and function cosegregate in gammadelta T cells.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 011955259

Download citation: RISBibTeXText

Related references

Different Potentials of T Cell Subsets in Regulating Airway Responsiveness: V1+ Cells, but not V4+ Cells, Promote Airway Hyperreactivity, Th2 Cytokines, and Airway Inflammation. The Journal of Immunology 172(5): 2894-2902, 2004

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. Journal of Clinical Investigation 103(2): 175-183, 1999

The effects of CD8+gammadelta T cells on late allergic airway responses and airway inflammation in rats. Journal of Allergy and Clinical Immunology 112(3): 547-555, 2003

Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells. American Journal of Respiratory and Critical Care Medicine 182(4): 464-476, 2010

Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice. Chest 107(3): 131s, 1995

Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 46(2): 288-297, 2016

Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. Journal of Allergy and Clinical Immunology 117(4): 787-794, 2006

Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation?. European Respiratory Journal 15(5): 961-968, 2000

Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. Journal of Allergy and Clinical Immunology 101(6 Pt 1): 778-785, 1998

PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunology 3(1): 81-91, 2010

P25 Relationships between airway hyper-responsiveness, airway inflammation and airway calibre in asthmatic subjects. Thorax 65(Suppl 4): A86-A87, 2010

Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage. Science 279(5357): 1729-1733, 1998

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. Journal of Clinical Investigation 94(5): 2028-2035, 1994

In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation. Journal of Immunology 174(11): 6955-6966, 2005

Airway exposure to bacterial superantigen (SEB) induces lymphocyte-dependent airway inflammation associated with increased airway responsiveness--a model for non-allergic asthma. European Journal of Immunology 29(3): 1021-1031, 1999