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Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences



Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences



Journal of Cell Science 117(Pt 19): 4603-4614



Previous work has demonstrated a more decondensed large-scale chromatin structure and a more internal nuclear position for gene-rich versus gene-poor chromosome regions. Here, we show that large-scale chromatin opening and changes in intranuclear positioning of chromosome regions can be induced by normal levels of endogenous transcription factors acting on mammalian regulatory sequences.

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Accession: 011958192

Download citation: RISBibTeXText

PMID: 15331668

DOI: 10.1242/jcs.01330


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Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing b-globin regulatory sequences. Journal of Cell Science 117(19): 03-14, 2004

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