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Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein



Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein



Experimental Cell Research 312(2): 156-170



Human wild type (WT) and mutant alpha-synuclein (alpha-syn) genes were overexpressed using a Tet-on expression system in stably transfected dopaminergic MN9D cells. Their overexpression induced caspase-independent and doparnine-related apoptosis not rescued by general caspase inhibitor Z-VAD-FMK.

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Accession: 011975881

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PMID: 16297908

DOI: 10.1016/j.yexcr.2005.10.012


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