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Drug-drug interactions of anti-infective drugs: utility of fluorescence cyp inhibition assays in drug discovery



Drug-drug interactions of anti-infective drugs: utility of fluorescence cyp inhibition assays in drug discovery



Drug Metabolism and Drug Interactions 21(3-4): 163-185



Drug interactions are often a result of induction or inhibition of cytochrome P450 (CYP) enzymes by co-administered drugs. A high throughput fluorescence assay using cDNA-expressed human CYP isozymes and fluorogenic substrates has been reported for the study of CYP inhibition. We used this assay to evaluate CYP inhibition profiles of 21 marketed anti-infective drugs.

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Accession: 011978921

Download citation: RISBibTeXText

PMID: 16841512

DOI: 10.1515/dmdi.2006.21.3-4.163


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