ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription
Beischlag, T.V.; Perdew, G.H.
Journal of Biological Chemistry 280(22): 21607-21611
2005
ISSN/ISBN: 0021-9258
PMID: 15837795
DOI: 10.1074/jbc.c500090200
Accession: 011983635
The aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) form a heterodimeric transcription factor upon binding a wide variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AHR target gene activation can be repressed by estrogen and estrogen-like compounds.
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