+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age



Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age



Chest 127(2): 502-508



Study objectives: We sought to identify early life factors (ie, first 4 years) associated with wheeze, asthma, and bronchial hyperresponsiveness (BHR) at age 10 years, comparing their relative influence for these conditions. Methods: Children were seen at birth, and at 1, 2, 4, and 10 years of age in a whole-population birth cohort study (1,456 subjects). Information was collected prospectively on genetic and environmental risk factors. Skin-prick testing was performed at 4 years of age. Current wheeze (in the last 12 months) and currently diagnosed asthma (CDA) (ie, current wheeze and ever-diagnosed asthmatic subject) were recorded at 10 years of age when BHR was measured at bronchial challenge. Independent significant risk factors for these outcomes were identified by logistic regression. Results: Independent significance for current wheeze occurred with maternal asthma (odds ratio (OR), 2.08; 95% confidence interval (CI), 1.27 to 3.41) and paternal asthma (OR,. 2.12; 95% CI 1.29 to 3.51), recurrent chest infections at 2 years (OR, 3.98; 95% CI, 2.36 to 6.70), atopy at 4 years of age (OR, 3.69; 95% CI, 2.36 to 5.76), eczema at 4 years of age (OR, 2.15; 95% CI, 1.24 to 3.73), and parental smoking at 4 years of age (OR, 2.18; 95% CI, 1.25 to 3.81). For CDA, significant factors were maternal asthma (OR, 2.26; 95% CI, 1.24 to 3.73), paternal asthma (OR, 2.30; 95% CI, 1.17 to 4.52), and sibling asthma (OR, 2.00; 95% CI, 1.16 to 3.43), recurrent chest infections at I year of age (OR, 2.67; 95% CI, 1.12 to 6.40) and 2 years of age (OR, 4.11; 95% CI, 2.06 to S. IS), atopy at 4 years of age (OR, 7.22; 95% CI, 4.13 to 12.62), parental smoking at I year of age (OR, 1.99; 95% CI, 1.15 to 3.45), and male gender (OR, 1.72; 95% CI, 1.01 to 2.95). For BHR, atopy at 4 years of age (OR, 5.38; 95% CI, 3.06 to 9.47) and high social class at birth (OR, 2.03; 95% CI, 1.16 to 3.53) proved to be significant. Conclusions: Asthmatic heredity, predisposition to early life atopy, plus early passive smoke exposure and recurrent chest infections are important influences for the occurrence of wheeze and asthma at 10 years of age. BHR at 10 years of age has a narrower risk profile, suggesting that factors influencing wheezing symptom expression may differ from those predisposing the patient to BHR.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011985261

Download citation: RISBibTeXText

PMID: 15705988

DOI: 10.1378/chest.127.2.502


Related references

Risk factors for asthma, allergy and bronchial hyperresponsiveness in children aged 6-8 years old. Anales Espanoles de Pediatria 55(3): 205-212, 2001

Current prevalence of asthma, allergy and bronchial hyperresponsiveness in children aged 6 to 8 years old. Anales Espanoles de Pediatria 54(1): 18-26, 2001

Impact of climatic and meteorologic factors on bronchial hyperresponsiveness and the course of asthma disease as well as their potential role in asthma prevention hypotheses methodical approaches and current concepts. Zeitschrift fuer Erkrankungen der Atmungsorgane 173(2): 116-126, 1989

Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age. American Journal of Respiratory and Critical Care Medicine 176(5): 446-453, 2007

Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 56(1): 4-8, 2001

Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 56(1): 4-8, 2001

Individual allergens as risk factors for asthma and bronchial hyperresponsiveness in Chinese children. European Respiratory Journal 19(2): 288-293, 2002

Fish Oil Supplementation During Pregnancy May Reduce Risk of Persistent Wheeze or Asthma in Children in First Five Years of Life. Explore 13(4): 279-280, 2017

Perinatal risk factors for bronchial hyperresponsiveness and atopy after a follow-up of 20 years. Journal of Allergy and Clinical Immunology 114(2): 270-276, 2004

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers. Journal of Occupational Health 58(1): 7, 2016

Article reviewed: Obesity is a risk factor for asthma and wheeze but not airway hyperresponsiveness. Sleep Medicine 2(5): 467-468, 2001

Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354(9178): 541-545, 1999

Risk factors for bronchial hyperresponsiveness in late childhood and early adolescence. European Respiratory Journal 20(3): 635-639, 2002

Bronchial hyperresponsiveness in young students of southern China: relation to respiratory symptoms, diagnosed asthma, and risk factors. Thorax 45(11): 860-865, 1990

Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort. Pediatrics 134(Suppl. 3): S162-S163, 2014