+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions



Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions



International Journal of Pharmaceutics 288(1): 27-34



This study evaluated the effects of combined use of two nonionic surfactants on the characteristics (i.e., appearance, emulsification time, and particle size) of oil-in-water microemulsions generated from flurbiprofen-loaded preconcentrates. Three phase diagrams were constructed using Capmul PG8 (propylene glycol monocaprylate) as the oil, Tween 20 (polysorbate 20) and/or Cremophor EL (polyoxyl 35 castor oil) as surfactants. A number of preconcentrates were selected based on phase diagrams: O20T80 (20% Capmul PG8, 80% Tween 20), O20C80 (20% Capmul PG8, 80% Cremophor EL), O20T40C40 (20% Capmul PG8, 40% Tween 20, 40% Cremophor EL). Flurbiprofen loading in preconcentrates was tested at 0%, 1%, 2.5%, and 5% (w/w). The resulting mixtures of these preconcentrates upon dilution 100-fold with aqueous medium were characterized by visual and microscopic observation, HPLC and photon correlation spectroscopy. (a) For preconcentrates using single surfactant, either O20T80 or O20C80, the dilution generated emulsions with visible cloudiness. The particle size increased as the drug loading increased; (b) for preconcentrates using two surfactants O20T40C40, the dilution generated clear microemulsions with small particle sizes (10-11nm), and the increased drug loading seemed to have little effect on the particle size. The microemulsions from preconcentrate O20T40C40 was also found to be stable at ambient temperature over 20 days without significant change in particle size at different drug loadings. Dilution with different aqueous medium, either water, or simulated gastric fluid or simulated intestinal fluid, also did not change the particle sizes of the microemulsions. The combined use of surfactants in preconcentrate showed the promise in generating desired self-emulsifying microemulsions with small particle size, increased drug loading, and improved physical stability. This will have significant implications in future dosage development for poorly water-soluble drugs in using self-emulsifying microemulsions drug delivery system (SMEDDS).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011993634

Download citation: RISBibTeXText

PMID: 15607255

DOI: 10.1016/j.ijpharm.2004.08.024


Related references

Microemulsions Formation on Water/Nonionic Surfactant/Peppermint Oil Mixtures. Journal of Dispersion Science and Technology 30(3): 399-405, 2009

Formation of single-phase microemulsions in toluene/water/nonionic surfactant systems. Langmuir 24(9): 4485-4493, 2008

Lipoxygenase catalyzed hydroperoxide formation in microemulsions containing nonionic surfactant. Biotechnology Letters. 14(12): 1153-1158, 1992

Evaluation Of Textile Detergent Efficiency Of Microemulsions In Systems Of Water Nonionic Surfactant And Hydrocarbon At Low Temperature. Journal of Dispersion Science and Technology 6(5): 523-537, 1985

Surfactant Chain Length Effect on the Structural Parameters of Nonionic Microemulsions. Journal of Dispersion Science and Technology 29(2): 289-296, 2008

Interfacial tension and the behavior of microemulsions and macroemulsions of water and carbon dioxide with a branched hydrocarbon nonionic surfactant. Journal of Supercritical Fluids 55(2): 712-723, 2010

Combined effect of nonionic surfactant Tween 80 and DOM on the behaviors of PAHs in soil--water system. Chemosphere 62(11): 1907-1916, 2006

Formation of fluorinated nonionic surfactant microemulsions in hydrofluorocarbon 134a (HFC 134a). Journal of Colloid and Interface Science 258(2): 345-353, 2003

The effect of sodium chloride on the formation of W/O microemulsions in soy bean oil/surfactant/water systems and the solubilization of small hydrophilic molecules. Colloids and Surfaces A: Physicochemical and Engineering Aspects 315(1-3): 130-135, 2008

Phase behavior in water nonionic surfactant hydrocarbon and water nonionic surfactant amphiphilic oil systems. Journal of Colloid & Interface Science 133(1): 237-243, 1989

Interfacial composition and characterization of a quaternary water-in-oil mixed surfactant (cationic of different alkyl chain lengths+polyoxyethylene type nonionic) microemulsions in absence and presence of inorganic salts. Colloids and Surfaces A: Physicochemical and Engineering Aspects 433: 219-229, 2013

Nonionic oil-in-water microemulsions The effect of oil incorporation. Journal of Pharmacy & Pharmacology 49(Suppl. 4): 28, 1997

Phase Behavior of Bicontinuous and Water/Diesel Fuel Microemulsions Using Nonionic Surfactants Combined with Hydrophilic Alcohol Ethoxylates. Journal of Dispersion Science and Technology 36(1): 10-17, 2015

FurfuralCysteine Model Reaction in Food Grade Nonionic Oil/Water Microemulsions for Selective Flavor Formation. Journal of Agricultural and Food Chemistry 50(10): 2878-2883, 2002

Microemulsions from silicone oil with an anionic/nonionic surfactant mixture. Physical Chemistry Chemical Physics 13(8): 3248-3256, 2011