+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of fish oil on oxidative stress, lipid profile and renal function in IgA nephropathy



Effect of fish oil on oxidative stress, lipid profile and renal function in IgA nephropathy



Journal of the Medical Association of Thailand 87(2): 143-149



The omega-3 polyunsaturated fatty acids in fish oil have been shown to produce beneficial effects, such as a reduction in blood pressure, proteinuria, lipid levels and inflammation. Aggregated immunoglobulin A obtained from IgA nephropathy patients induced greater oxygen free radicals in polymorphonuclear leukocytes than other glomerulopathy. All of which may affect the course of IgA nephropathy. Twenty-three adult patients with biopsy proven IgA nephropathy, with proteinuria more than 1 g/day, serum creatinine less than 3 mg/dl and blood pressure control less than 130/80 mmHg were given omega-3 polyunsaturated fatty acids (PUFA) in the form of an Omacor capsule 4 g/day equivalent to eicosapentaenoic acid (EPA) 1.88 g and docosahexaenoic acid (DHA) 1.48 g for 6 months. A 3 to 6 month follow-up was planned, with monthly evaluations of the patients. By six months, the serum triglyceride was significantly reduced (143.45 +/- 62.65 vs 91 +/- 42.89 mg/dl, p = 0.002), serum cholesterol was also reduced but not statistically significant (234.16 +/- 56.29 vs 219.76 +/- 51.25 mg/dl, p = 0.07). There was a trend of increased serum high density lipoprotein (HDL)-cholesterol (39.26 +/- 10.56 vs 42.72 +/- 8.37 mg/dl, p = 0.056). Urine beta-2-microglobulin was elevated in IgA patients and decreased statistically significant after 3 months (453 +/- 580 vs 308 +/- 274 microg/24 h, p < 0.001) and 6 months of fish oil therapy (453 +/- 580 vs 142 +/- 182, p < 0.03) while urine N-acetyl-glucosaminidase (NAG) was of no significant difference both before and after fish oil administration (21 +/- 10 vs 22 +/- 10 and 21 +/- 9 U/24 h, p = 0.08). Plasma malondialdehyde (MDA), the end product of oxidative stress was statistically, significantly decreased (1.09 +/- 0.51 vs 0.89 +/- 0.49 nmol/L, p = 0.003). The study did not show any change in blood pressure, proteinuria, or serum creatinine. The authors conclude from the results of this study that patients with idiopathic IgA nephropathy with proteinuria and mildly reduced GFR did not benefit from short-term treatment with 4 g per day of omega-3 PUFA regarding the total protein excretion and glomerular filtration rate (GFR), but the advantage was the improvement in tubular dysfunction, lipid profiles, and oxidative stress.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 011996189

Download citation: RISBibTeXText

PMID: 15061297


Related references

The effect of the initiation of renal replacement therapy on lipid profile and oxidative stress during the first 6 months of treatment. Clinica Chimica Acta; International Journal of Clinical Chemistry 361(1-2): 112-118, 2005

Alpha-Lipoic acid attenuates renal pathology and renal function in diabetic nephropathy via reducing oxidative stress. Journal of the American Society of Nephrology 14(Abstracts Issue): 387A, 2003

Protective Effects of Curcumin on Renal Oxidative Stress and Lipid Metabolism in a Rat Model of Type 2 Diabetic Nephropathy. Yonsei Medical Journal 57(3): 664-673, 2016

Effects of lipid-lowering therapy with rosuvastatin on kidney function and oxidative stress in patients with diabetic nephropathy. Journal of Atherosclerosis and Thrombosis 18(11): 1018-1028, 2011

Effects of extra virgin olive oil and fish oil on lipid profile and oxidative stress in patients with metabolic syndrome. Nutrition 31(6): 834-840, 2015

Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food and Chemical Toxicology 42(12): 2053-2060, 2004

Alterations in lipid profile, oxidative stress and hepatic function in rat fed with saccharin and methyl-salicylates. International Journal of Clinical and Experimental Medicine 8(4): 6133-6144, 2015

Punica granatum improves renal function in gentamicin-induced nephropathy in rats via attenuation of oxidative stress. Journal of Ayurveda and Integrative Medicine 2018:, 2018

The effect of caloric restriction on lipid profile and oxidative stress in rats. Free Radical Biology & Medicine 31(10): S37, 2001

Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial. Nutrition and Metabolism 8(1): 32, 2011

Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis. Journal of Renal Nutrition 22(2): 244-250, 2012

Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. Bmc Complementary and Alternative Medicine 8: 21, 2008

Effect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients. Pakistan Journal of Biological Sciences 14(19): 900-904, 2011

The effect of calcitriol on lipid profile and oxidative stress in hyperlipidemic patients with type 2 diabetes mellitus. Arya Atherosclerosis 10(2): 82-88, 2014

The effect ofGongronema latifoliumextracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. Journal of Biosciences 28(1): 1-5, 2003