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Effects of fimbria-fornix, hippocampus, and amygdala lesions on discrimination between proximal locations



Effects of fimbria-fornix, hippocampus, and amygdala lesions on discrimination between proximal locations



Behavioral Neuroscience 118(4): 770-784



The conditioned cue preference (CCP) task was used to study the information required to discriminate between spatial locations defined by adjacent arms of an 8-arm radial maze. Normal rats learned the discrimination after 3 unreinforced preexposure (PE) sessions and 4 food paired-unpaired training trials. Fimbria-fornix lesions made before, but not after, PE, and hippocampus lesions made at either time, blocked the discrimination, suggesting that the 2 structures processed different information. Lateral amygdala lesions made before PE facilitated the discrimination. This amygdala-mediated interference with the discrimination was the result of a conditioned approach response that did not discriminate between the 2 arm locations. A hippocampus/fimbria-fornix system and an amygdala system process different information about the same learning situation simultaneously and in parallel.

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Accession: 012015056

Download citation: RISBibTeXText

PMID: 15301603

DOI: 10.1037/0735-7044.118.4.770


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