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Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1

Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1

Journal of General Virology 87(Pt 3): 623-627

ISSN/ISBN: 0022-1317

PMID: 16476983

DOI: 10.1099/vir.0.81371-0

Maturation of hepatitis C virus (HCV) core protein requires cleavage by signal peptidase (SP) and signal peptide peptidase (SPP) at a signal peptide between core and the El glycoprotein. For HCV strain Glasgow, amino acids Ala(180), Ser(183) and CYS184 within the signal peptide have previously been shown to be essential for efficient SPP cleavage. By contrast, these residues apparently did not contribute to core maturation in HCV strain J1.

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Accession: 012027864

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