+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffolds

, : Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffolds. Tissue Engineering 10(9-10): 1376-1385

Tissue engineering has provided an alternative to traditional strategies to repair cartilage damaged by injury or degenerative disease. A successful strategy to engineer osteochondral tissue will mimic the natural contour of the articulating surface, achieve native mechanical properties and functional load-bearing ability, and lead to integration with host cartilage and underlying subchondral bone. Image-based design ( IBD) and solid free-form (SFF) fabrication can be used to generate scaffolds that are load bearing and match articular geometry. The objective of this study was to utilize materials and biological factors in an integrated approach to regenerate a multitissue interface. Biphasic composite scaffolds manufactured by IBD and SFF fabrication were used to simultaneously generate bone and cartilage in discrete regions and provide for the development of a stable interface between cartilage and subchondral bone. Poly-L-lactic acid/hydroxyapatite composite scaffolds were differentially seeded with fibroblasts transduced with an adenovirus expressing bone morphogenetic protein 7 (BMP-7) in the ceramic phase and fully differentiated chondrocytes in the polymeric phase. After subcutaneous implantation into mice, the biphasic scaffolds promoted the simultaneous growth of bone, cartilage, and a mineralized interface tissue. Within the ceramic phase, the pockets of tissue generated included blood vessels, marrow stroma, and adipose tissue. This combination of IBD and SFF-fabricated biphasic scaffolds with gene and cell therapy is a promising approach to regenerate osteochondral defects.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 012038900

PMID: 15588398

DOI: 10.1089/ten.2004.10.1376

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Ljubesic, J., 1985: Changes in body measurements of Lipitsa stallions at principal studs in Yugoslavia. Body measurements of 129 stallions at 4 studs, recorded in 1919-81, are tabulated. Height at withers increased from 155-168 to 160-172 cm, heart girth from 170-189 to 180-205 cm, and cannon bone circumference from 18.5-19.0 cm to 19.0-21.5 cm.

Persson, F.; Carlsson, L.; Duker, Göran.; Jacobson, I., 2005: Blocking characteristics of hERG, hNav1.5, and hKvLQT1/hminK after administration of the novel anti-arrhythmic compound AZD7009. Introduction: AZD7009 is a novel anti-arrhythmic compound under development for short- and long-term management of atrial fibrillation and flutter. Electrophysiological studies in animals have shown high anti-arrhythmic efficacy, predominant actio...

Ein-Dor, T.; Mikulincer, M.; Shaver, P. R., 2011: Effective Reaction to Danger Attachment Insecurities Predict Behavioral Reactions to an Experimentally Induced Threat Above and Beyond General Personality Traits. People who score high on attachment anxiety or avoidance display poorer adjustment than secure individuals in various social, emotional, and behavioral domains. Yet it may be advantageous for groups to include insecure as well as secure members. T...

Suzuki, T.; Aoki, N., 1962: On the stratigraphy and the foraminiferal fossils of the Jizodo and the Yabu Formations, Northwest of Mobara, Boso Peninsula. Journal of the Geological Society of Japan, 68: 497-506

Poni, S.; Intrieri, C.; Magnanini, E., 1999: Set-up, calibration and testing of a custom-built system for measuring whole-canopy transpiration in grapevine. Upgrading of a whole-vine gas exchange system able to take automated measurements of canopy water loss under close-to-ambient conditions is reported. Vine canopies are enclosed in clear, inflated polyethylene chambers fed with ambient air at a flo...

Mccarthy, James R.; Heinrichs, Stephen C.; Grigoriadis, Dimitri E., 1999: Recent advances with the CRF1 receptor Design of small molecule inhibitors, receptor subtypes and clinical indications. Current Pharmaceutical Design 5(5): 289-315, May

Peleshenko, A. B.; Lutay, N. V., 2003: Free and IgG-bounded fibronectin in sclerodermia systematica. Molecular & Cellular Proteomics 2(9): 967, September

Ganguly, Sumana; Sircar, S. M., 1964: Cell growth and metabolism of pea internodes as affected by the growth substances from the root of water hyacinth. Bull Bot Soc Bengal 18(1/2): 83-86

Delassus, M., 1970: Observations on sorghum disease in Maggia soil. Sols africains African soils: 15 (1 3) 101-108

Cunha Da Silva, J. A., 1945: Brazil's forest heritage.. The forests of Brazil may be divided into three ecologically distinct types: (1) the Amazonian forest; (2) the tropical forest; and (3) the forests of the Parana River Valley. The most important commercial species of each area are noted and a list...