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Enhancer-dependent splicing of FGFR1 alpha-exon is repressed by RNA interference-mediated down-regulation of SRp55

Jin, W.; Cote, G.J.

Cancer Research 64(24): 8901-8905

2004


ISSN/ISBN: 0008-5472
PMID: 15604250
DOI: 10.1158/0008-5472.can-04-0716
Accession: 012041475

The FGFR1 gene transcript is alternatively processed to produce functionally different receptor forms. Previously, we identified a 69-nucleotide exonic splicing enhancer (ESE) required for alpha-exon inclusion in JEG3 cells. In the present study, we found that this sequence is composed of three independent elements, two smaller ESE sequences flanking an exonic splicing silencer sequence.

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