Section 13
Chapter 12,042

Enhancer-dependent splicing of FGFR1 alpha-exon is repressed by RNA interference-mediated down-regulation of SRp55

Jin, W.; Cote, G.J.

Cancer Research 64(24): 8901-8905


ISSN/ISBN: 0008-5472
PMID: 15604250
DOI: 10.1158/0008-5472.can-04-0716
Accession: 012041475

The FGFR1 gene transcript is alternatively processed to produce functionally different receptor forms. Previously, we identified a 69-nucleotide exonic splicing enhancer (ESE) required for alpha-exon inclusion in JEG3 cells. In the present study, we found that this sequence is composed of three independent elements, two smaller ESE sequences flanking an exonic splicing silencer sequence.

PDF emailed within 0-6 h: $19.90