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ErbB2 is required for ductal morphogenesis of the mammary gland



ErbB2 is required for ductal morphogenesis of the mammary gland



Proceedings of the National Academy of Sciences of the United States of America 101(49): 17138-17143



The ERBB2/HER2/NEU receptor tyrosine kinase gene is amplified in up to 30% of human breast cancers. The frequent and specific selection of this receptor kinase gene for amplification in breast cancer implies that it has important normal functions in the mammary gland. To investigate the functions of ErbB2 during normal mouse mammary gland development, we transplanted mammary buds from genetically rescued ErbB2-/- embryos that express ErbB2 in the cardiac muscle.

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Accession: 012047398

Download citation: RISBibTeXText

PMID: 15569931

DOI: 10.1073/pnas.0407057101



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