+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Evaluation of metabolic syndrome frequency and premature carotid atherosclerosis in young women with polycystic ovary syndrome



Evaluation of metabolic syndrome frequency and premature carotid atherosclerosis in young women with polycystic ovary syndrome



Human Reproduction 20(9): 2409-2413



The aim of this study was to evaluate metabolic syndrome frequency, cardiovascular risk profile and premature carotid artery atherosclerosis in patients with polycystic ovary syndrome (PCOS) especially during early adulthood. A case-control study was conducted on 43 young women (18-22 years of age) with PCOS and 43 age-matched volunteer controls. Anthropometrical measurements, hormone levels, lipid and glucose profile were obtained from all subjects. Two different criteria were used to assess metabolic syndrome (MS) frequency. Common carotid artery intima-media thickness (IMT) was measured and stepwise multiple linear regression analysis was used to identify the independent cardiovascular risk factors that predict IMT. MS was diagnosed in 11.6% (n = 5) of women with PCOS compared to no cases in the control group (P = 0.02). The mean IMT was significantly higher in PCOS subjects (0.746 +/- 0.106 mm) compared to controls (0.608 +/- 0.105 mm, P < 0.001). Among many cardiovascular risk factors evaluated, the diagnosis of PCOS, increased body mass index and decreased sex hormone-binding globulin were significant independent predictors of increased IMT. These findings indicate that adolescence may be a more appropriate time to intervene for PCOS patients, as many cardiovascular risks are already present during early adulthood. As far as IMT is concerned, mechanisms other than hyperandrogenaemia and obesity might be operating as causative factors.

(PDF emailed within 0-6 h: $19.90)

Accession: 012058616

Download citation: RISBibTeXText

PMID: 15919774

DOI: 10.1093/humrep/dei100


Related references

Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arteriosclerosis Thrombosis & Vascular Biology 20(11): 2414-2421, November, 2000

Association of hyperandrogenemic and metabolic phenotype with carotid intima-media thickness in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 90(5): 2740-2746, 2005

Association of Hyperandrogenemic and Metabolic Phenotype with Carotid Intima-Media Thickness in Young Women with Polycystic Ovary Syndrome. Obstetric and Gynecologic Survey 61(2): 104-106, 2006

Frequency and risk factors for metabolic syndrome in adolescents and adults women with polycystic ovary syndrome. Revista Brasileira de Ginecologia E Obstetricia 34(8): 357-361, 2013

The metabolic syndrome in young Korean women with polycystic ovary syndrome. Diabetes Research and Clinical Practice 77 Suppl 1: S243-S246, 2007

Metabolic syndrome in young Czech women with polycystic ovary syndrome. Human Reproduction 20(12): 3328-3332, 2005

Optimal waist circumference for prediction of metabolic syndrome in young Korean women with polycystic ovary syndrome. Obesity: 3, 593-597, 2010

The natural history of the metabolic syndrome in young women with the polycystic ovary syndrome and the effect of long-term oestrogen-progestagen treatment. Clinical Endocrinology 50(4): 517-527, April, 1999

Carotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study. American Journal of Obstetrics and Gynecology 174(4): 1224-1232, 1996

Metabolic syndrome in young women with the polycystic ovary syndrome: revisiting the threshold for an abnormally decreased high-density lipoprotein cholesterol serum level. Bjog 117(2): 175-180, 2010

Young obese women with polycystic ovary syndrome have evidence of early coronary atherosclerosis. Journal of Clinical Endocrinology and Metabolism 92(12): 4609-4614, 2007

Racial and ethnic differences in the prevalence of metabolic syndrome and its components of metabolic syndrome in women with polycystic ovary syndrome: a regional cross-sectional study. American Journal of Obstetrics and Gynecology 217(2): 189.E1-189.E8, 2017

Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome. Clinical Endocrinology 51(1): 97-99, July, 1999

Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?. Archives of Gynecology and Obstetrics 294(2): 403-409, 2017

The evaluation of carotid intima-media thickness and visceral obesity as an atherosclerosis predictor in newly-diagnosed polycystic ovary syndrome. La Clinica Terapeutica 165(1): E6-11, 2016