+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells

Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells

Anticancer Research 25(4): 2737-2741

Background: hRFI is a newly discovered gene encoding a Ring Finger domain highly homologous to that of the X-chromosome-linked inhibitor of apoptosis protein, which is among the most potent inhibitors of apoptosis. The hRFI protein is preferentially expressed in colorectal cancers, although its actual function is unknown. The aim of this study was to determine whether hRFI possesses an anti-apoptotic function in colorectal cancer cells against chemotherapeutic agents.

(PDF emailed within 1 workday: $29.90)

Accession: 012067742

Download citation: RISBibTeXText

PMID: 16080519

Related references

Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. Molecular Cancer Therapeutics 4(5): 743-750, 2005

Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappa B andupregulation of BCL-2 and BCL-XL. Oncogene 25(22): 3160-3169, 2006

Inhibition of multidrug resistance-associated protein expression in neuroblastoma cells induces spontaneous differentiation, apoptosis and reduced Bcl-2 expression. Proceedings of the American Association for Cancer Research Annual Meeting 40: 224, March, 1999

Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells. International Journal of Oncology 47(5): 1663-1671, 2016

Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells. Cancer Letters 301(1): 38-46, 2011

Effect of protein kinase C on multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cells. Di 1 Jun Yi Da Xue Xue Bao 22(7): 626-628, 2002

Poly-γ-glutamic acid induces apoptosis via reduction of COX-2 expression in TPA-induced HT-29 human colorectal cancer cells. International Journal of Molecular Sciences 16(4): 7577-7586, 2016

Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5'-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs. Plos One 10(8): E0136080-E0136080, 2016

Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells. Pharmaceutical Biology 53(4): 540-547, 2015

SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Letters 277(1): 29-37, 2009

Gamma-TQ overcomes multidrug-resistance and induces apoptosis in leukemia cells. FASEB Journal 15(4): A378, March 7, 2001

Celecoxib induces cell apoptosis coupled with up-regulation of the expression of VEGF by a mechanism involving ER stress in human colorectal cancer cells. Oncology Reports 26(2): 495-502, 2011

Relationship between expression of genes regulating apoptosis and genes conferring multidrug resistance in cancer cells. International Journal of Oncology 11(SUPPL ): 904, 1997

Expression of exogenous NF-IL6 induces apoptosis in Sp2/0-Ag14 myeloma cells. Dna and Cell Biology 16(2): 127-135, 1997

Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape. Archives of Pathology & Laboratory Medicine 126(6): 686-691, 2002