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Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells



Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells



Anticancer Research 25(4): 2737-2741



Background: hRFI is a newly discovered gene encoding a Ring Finger domain highly homologous to that of the X-chromosome-linked inhibitor of apoptosis protein, which is among the most potent inhibitors of apoptosis. The hRFI protein is preferentially expressed in colorectal cancers, although its actual function is unknown. The aim of this study was to determine whether hRFI possesses an anti-apoptotic function in colorectal cancer cells against chemotherapeutic agents.

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Accession: 012067742

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PMID: 16080519



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