+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Experimental Helicobacter pylori infection induces antral-predominant, chronic active gastritis in hispid cotton rats (Sigmodon hispidus)

Experimental Helicobacter pylori infection induces antral-predominant, chronic active gastritis in hispid cotton rats (Sigmodon hispidus)

Helicobacter 10(4): 332-344

ISSN/ISBN: 1083-4389

PMID: 16104950

DOI: 10.1111/j.1523-5378.2005.00320.x

The hispid cotton rat has proven to be an excellent animal model for a variety of human infectious disease agents. This study was performed to evaluate the use of the cotton rat as a model of Helicobacter pylori infection. Thirty-eight inbred cotton rats were orogastrically inoculated with a human strain of H. pylori. Twenty-eight control cotton rats were dosed with vehicle only. Animals were sacrificed at 2, 4, 12, 26, or 38 weeks after inoculation for bacterial and histologic and immunologic examinations. Helicobacter pylori was cultured from the glandular stomach of 89% of the infected cotton rats. The level of colonization was consistently high (approximately 10(4-6) colony-forming units/g tissue). Histologically, the spiral bacteria were demonstrated on the epithelial surface and in the foveolae of the gastric mucosa with highest numbers in the antrum. H. pylori infection was associated with antral-predominant, chronic active gastritis which progressively increased in severity over time. By week 26 of infection, moderate antral gastritis had developed with frequent involvement of the submucosa and formation of lymphocytic aggregates. Splenic T cells from infected cotton rats expressed mRNAs for interferon-gamma, interleukin-4, interleukin-6, and interleukin-10 following in vitro stimulation with H. pylori. Serum levels of H. pylori-specific immunoglobulin G were significantly elevated after 12 weeks of infection. The H. pylori-infected cotton rat represents a novel animal model that should prove useful for studies of H. pylori-induced chronic active gastritis and factors affecting gastric colonization by this pathogen.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012068625

Download citation: RISBibTeXText

Related references

Helicobacter pylori infection induces chronic active gastritis in cotton rats. Gastroenterology 122(4 Suppl 1): A 532-A 533, 2002

Pathology of Black Creek Canal virus infection in juvenile hispid cotton rats (Sigmodon hispidus). Vector Borne and Zoonotic Diseases 10(6): 621-628, 2010

Use of coastal wetlands by hispid cotton rats (Sigmodon hispidus). Southwestern Naturalist 50(3): 397-402, 2005

Self-Selection of Diet by Hispid Cotton Rats ( Sigmodon Hispidus ). Psychological Reports 41(2): 343-346, 1977

Differential burrowing by hispid cotton rats (Sigmodon hispidus: Rodentia). Southwestern Naturalist 234: 696-699, 1978

Self selection of diet by hispid cotton rats sigmodon hispidus texianus. Psychological Reports 41(2): 343-346, 1977

Experimental Helicobacter pylori infection induces antral gastritis and gastric mucosa-associated lymphoid tissue in guinea pigs. Infection and Immunity 66(6): 2614-2618, 1998

Alternatives to retroorbital blood collection in hispid cotton rats (Sigmodon hispidus). Journal of the American Association for Laboratory Animal Science: Jaalas 51(2): 239-245, 2012

Measuring similarity among hispid cotton rats (Sigmodon hispidus) of known relatedness with DNA fingerprinting. Journal of Mammalogy 79(2): 594-603, 1998

Population dynamics of hispid cotton rats (Sigmodon hispidus) across a nitrogen-amended landscape. Canadian Journal of Zoology 81(6): 4-1003, 2003

Subspecific variation in life-history traits of hispid cotton rats (Sigmodon hispidus). Journal of Mammalogy 78(2): 613-625, 1997

Diversifying animal models: the use of hispid cotton rats (Sigmodon hispidus) in infectious diseases. Laboratory Animals 36(4): 357-372, 2002

The hispid cotton rat (Sigmodon hispidus) as an experimental host for the bovine liver fluke (Fasciola hepatica). Veterinary Parasitology 87(2-3): 125-132, 2000

Toxicity of 2,4,6-Trinitrotoluene (Tnt) in Hispid Cotton Rats ( Sigmodon hispidus ): Hematological, Biochemical, and Pathological Effects. International Journal of Toxicology 19(3): 169-177, 2000

Experimentally Induced Habitat Shifts by Hispid Cotton Rats (Sigmodon hispidus): Response to Protein Supplementation. Journal of Mammalogy 77(1): 232-239, 1996