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Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease



Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease



Archives of Neurology 62(1): 96-98



Background: Recently, a triplication of the a-synuclein locus was found associated with autosomal dominant Parkinson disease in a large family. Objective: To determine whether a triplication or some other dosage alteration in the alpha-synuclein gene is present in one or more patients with familial PD in a large multinational collective. Design: Retrospective recruitment of the largest families who were willing to cooperate with the study.

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Accession: 012083646

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PMID: 15642855

DOI: 10.1001/archneur.62.1.96


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