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Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2

Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2

American Journal of Physiology. Cell Physiology 289(5): C1134-C1144

Inward rectifier K+ channels (Kir) are a significant determinant of endothelial cell (EC) membrane potential, which plays an important role in endothelium-dependent vasodilatation. In the present study, several complementary strategies were applied to determine the Kir2 subunit composition of human aortic endothelial cells (HAECs). Expression levels of Kir2.1, Kir2.2, and Kir2.4 mRNA were similar, whereas Kir2.3 mRNA expression was significantly weaker.

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Accession: 012105827

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PMID: 15958527

DOI: 10.1152/ajpcell.00077.2005

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