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Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1


Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1



Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society 54(5): 567-574



ISSN/ISBN: 0022-1554

PMID: 16401696

DOI: 10.1369/jhc.5a6827.2006

We present the generation of a panel of monoclonal antibodies (F55A10, F55A12, F64A6B4, and F65A2) against the homeodomain transcription factor Nkx6.1, one of the essential transcription factors that regulates the multistep differentiation process of precursor cells into endocrine beta-cells in the pancreas. Expression of Nkx6.1 can be detected in developing pancreatic epithelium and in adult insulin-producing beta-cells, making this transcription factor a unique beta-cell marker.

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Accession: 012115879

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