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Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice



Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice



American Journal of Physiology. Endocrinology and Metabolism 289(4): E703-E709



Genetic background is important in determining susceptibility to metabolic abnormalities such as insulin resistance and beta-cell dysfunction. Islet amyloid is associated with reduced beta-cell mass and function and develops in the majority of our C57BL/6J x DBA/2J (F-1) male human islet amyloid polypeptide (hIAPP) transgenic mice after 1 yr of increased fat feeding.

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Accession: 012117812

Download citation: RISBibTeXText

PMID: 15899941

DOI: 10.1152/ajpendo.00471.2004


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