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Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae



Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae



Cancer Research 65(13): 5890-5897



To identify novel genes that mediate cellular resistance to cisplatin, we have screened the collection of Saccharomyces cerevisiae deletion strains. We have found reproducibly 22 genes/open reading frames (ORF), which when deleted, confer resistance to cisplatin at a concentration that is lethal to wildtype cells. Complementation of individual deletion strains with the corresponding wild-type gene abolished cisplatin resistance, confirming that specific gene deletions caused the resistance.

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Accession: 012123101

Download citation: RISBibTeXText

PMID: 15994967

DOI: 10.1158/0008-5472.can-04-4093


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