Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3'-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin
Tillmar, L.; Welsh, N.
Molecular and Cellular Biochemistry 260(1-2): 85-90
2004
ISSN/ISBN: 0300-8177 PMID: 15228089 DOI: 10.1023/b:mcbi.0000026059.56089.e4
Accession: 012128699
Despite considerable knowledge on the regulation of insulin gene transcription, little is known about the post-transcriptional control mechanisms of this gene. We have recently reported glucose- and hypoxia-regulated binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidine-rich sequence of the 3'-untranslated insulin mRNA (ins-PRS), an event which may control insulin mRNA stability. The present aim was to probe for the signaling pathways that control this binding activity.