Section 13
Chapter 12,130

Glycoprotein VI/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen

Jarvis, G.E.; Best, D.; Watson, S.P.

Biochemical Journal 383(Pt. 3): 581-588


ISSN/ISBN: 0264-6021
PMID: 15283702
DOI: 10.1042/bj20040654
Accession: 012129934

We have investigated the ability of collagen to induce signalling and functional responses in suspensions of murine platelets deficient in the FcRgamma (Fc receptor gamma) chain, which lack the collagen receptor GPVI (glycoprotein VI). In the absence of the FcRgamma chain, collagen induced a unique pattern of tyrosine phosphorylation which was potentiated by the thromboxane analogue U46619.

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