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Glycoprotein gpTRL10 of human cytomegalovirus is dispensable for virus replication in human fibroblasts

Glycoprotein gpTRL10 of human cytomegalovirus is dispensable for virus replication in human fibroblasts

Archives of Virology 149(3): 495-506

Human cytomegalovirus (HCMV) has a coding capacity for glycoproteins which by far exceeds that of other herpesviruses. Few of these proteins have been characterized. Glycoprotein gpTRL10 represents a structural component of HCMV. The protein has no homologous counterparts in other herpesviruses. We have isolated bacterial artificial chromosomes (BACs) harboring the genome from the low passage clinical isolate PAN and constructed a deletion mutant in reading frame TRL10. Our results show that deletion of gpTRL10 has only minimal effects on viral replication in human fibroblasts.

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Accession: 012129937

Download citation: RISBibTeXText

PMID: 14991439

DOI: 10.1007/s00705-003-0228-0

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