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Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise

Shearer, J.; Fueger, P.T.; Rottman, J.N.; Bracy, D.P.; Binas, B.; Wasserman, D.H.

American Journal of Physiology. Endocrinology and Metabolism 288(2): E292-E297

2004


ISSN/ISBN: 0193-1849
PMID: 15454399
DOI: 10.1152/ajpendo.00287.2004
Accession: 012140929

The role of heart-type cytosolic fatty acid-binding protein (H-FABP) in mediating whole body and muscle-specific long-chain fatty acid (LCFA) and glucose utilization was examined using exercise as a phenotyping tool. Catheters were chronically implanted in a carotid artery and jugular vein of wild-type (WT, n = 8), heterozygous (H-FABP+/-, n = 8), and null (H-FABP-/-, n = 7) chow-fed C57BL/6J mice, and mice were allowed to recover for 7 days.

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