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High thymidylate synthase expression is typical for sporadic MSI-H colorectal carcinoma



High thymidylate synthase expression is typical for sporadic MSI-H colorectal carcinoma



Polish Journal of Pathology 57(1): 29-33



Colorectal carcinoma is etiopathologically heterogenic. It may develop through a sequence of mutations leading to chromosome instability or be a result of defects in DNA repair mechanisms manifested by microsatellite instability. Carcinomas of this type are supposed to be characterized by a better prognosis and a different response to chemotherapy. The main target of 5-fluorouracil (5-FU) treatment is thymidylate synthase (TS).

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Accession: 012149493

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PMID: 16739880


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