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Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression

Mahlknecht, U.; Will, J.; Varin, A.; Hoelzer, D.; Herbein, G.

Journal of Immunology 173(6): 3979-3990

2004

ISSN/ISBN: 0022-1767
PMID: 15356147
DOI: 10.4049/jimmunol.173.6.3979
Accession: 012153148
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During inflammatory events, the induction of immediate-early genes, such as TNF-alpha, is regulated by signaling cascades including the JAK/STAT, NF-kappaB, and the p38 MAPK pathways, which result in phosphorylation-dependent activation of transcription factors. We observed the direct interaction of histone deacetylase (HDAC) 3, a class I histone deacetylase, with MAPK11 (p38 beta isoform) by West-Western-based screening analysis, pull-down assay, and two-hybrid system analysis.

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