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Human 5' fwdarw 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites



Human 5' fwdarw 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites



Nature (London) 432(7016): 522-525



Eukaryotic protein-encoding genes possess poly(A) signals that define the end of the messenger RNA and mediate downstream transcriptional termination by RNA polymerase II (Pol II)1. Termination could occur through an 'anti-termination' mechanism whereby elongation factors dissociate when the poly(A) signal is encountered, producing termination-competent Pol II2,3.

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Accession: 012158261

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